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Advances in Cardiovascular Disease Management
Hereditary transthyretin amyloidosis (hATTR) is a rare, inherited condition that can affect multiple organs. It occurs when mutations in the transthyretin (TTR) gene destabilize the protein, causing it to misfold and form amyloid deposits. These deposits gradually damage tissues, leading to serious complications. Over 130 pathogenic variants have been identified, each associated with different symptoms and disease patterns.
Accreditation
Accredited by the Accreditation Council for Continuing Medical Education (ACCME)
Activity ID: CME-2026-CV-001
Faculty
Dr. Sarah Martinez, MD, FACC
Director of Cardiovascular Research, University Medical Center
Dr. James Chen, MD, PhD
Professor of Cardiology, Harvard Medical School
Learning Objectives
- • Identify the latest evidence-based guidelines for managing patients with heart failure
- • Evaluate the role of novel anticoagulation therapies in atrial fibrillation management
- • Apply risk stratification tools to optimize cardiovascular disease prevention strategies
- • Recognize key pharmacological updates in lipid management and diabetes care
Completion Requirements
- • Watch educational video (minimum 80% completion required)
- • Complete all assessment questions
- • Achieve a passing score of 70% or higher
- • Provide participant information for certificate
Educational Content
Symptoms of hATTR usually begin in adulthood and worsen over time, primarily affecting the neurological, cardiac, and autonomic systems.
Neurological signs may include:
- Numbness
- Tingling, shooting, or burning pain
- Muscle weakness
- Bilateral carpal tunnel syndrome
Autonomic issues often present as:
- Digestive problems
- Bladder dysfunction
- Orthostatic hypotension
Cardiac involvement can lead to:
- Heart failure
- Arrhythmias
- Shortness of breath
- Swelling
Other features include weight loss, kidney disease, eye problems such as glaucoma, and, in advanced cases, stroke-like episodes or cognitive decline. Early diagnosis is critical for better outcomes.
Assessment Complete
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