An analysis of nearly 900,000 patients with type 2 diabetes found GLP-1 drug use was associated with higher risks of smell and taste disturbances. In separate findings, dexamethasone reduced nausea and vomiting during the first days of morphine treatment in cancer patients.
An experimental immunosuppressant, tegoprubart, showed superior kidney function outcomes compared with tacrolimus in kidney transplant recipients. In separate findings, researchers identified antibodies targeting West Nile virus and reported three biologically distinct subtypes of severe pneumonia.
Practical takeaways from new NCCN guidance
An experimental ENPP1-blocking drug improved kidney repair and function in mouse models of kidney injury. In separate findings, researchers examined Ebola virus persistence in brain-like organoids and reported community spread of multidrug-resistant Klebsiella pneumoniae in the United States.
Researchers used a robotic platform to test drugs against persistent lung cancer cells and identified nine compounds with consistent activity. In separate findings, genicular artery embolization was associated with sustained reductions in pain and improvements in function in patients with knee osteoarthritis.
VTE models, ADAPT-BLEED, and DOAC vs warfarin
Treatment choices across breast cancer stages
MRI, PET–CT, and radiotherapy decisions
Genetics, fertility, and survivorship insights
An analysis of nearly 60,000 patients found regular glucosamine use was associated with a higher likelihood of progression from mild cognitive impairment to dementia. Separately, moderate screen time during the first days after concussion was associated with faster symptom resolution in adolescents.
In a small trial, Bacillus Calmette-Guérin immunotherapy improved HbA1c levels, reduced insulin use and increased time in the normal blood-sugar range in adults with long-standing type 1 diabetes. In separate findings, researchers evaluated lab-grown bacteria for recurrent C. difficile diarrhea and reported immune responses in a first-in-human Lassa fever and rabies vaccine trial.
Rapid, deep responses in early-phase study
κ subgroup benefit observed in CARES trial
Risk stratification using TILs, ctDNA, genomics
In small studies, CAR-T cell therapy reduced donor-directed antibodies and enabled kidney transplantation in highly sensitized patients. In separate findings, pilot studies reported improvements in rheumatoid arthritis, systemic sclerosis, lupus and other rheumatological diseases following CAR-T treatment.
In a late-stage trial, GammaTile implantation after brain metastasis surgery was associated with lower tumor regrowth and improved survival versus standard radiotherapy. In separate findings, teclistamab improved outcomes in relapsed multiple myeloma and a personalized mRNA vaccine reduced melanoma recurrence when added to Keytruda.
Phase 3 EA5142 results presented at ASCO 2026
POTOMAC shows stable OS and QoL
HARMONi-6 shows OS benefit vs PD-1
PROTEUS shows improved MFS outcomes
